Inclusion Criteria:

- Female between 18 and 70 years old;

- Patients with histologic proved metastatic breast cancer, unsuitable to be treated
with surgery;

- ECOG 0~1;

- Normal functions with heart, liver,renal and bone marrow:WBC≥3.5×109/L；Hb≥90
g/L；plt≥100×109/L;

- Got ICF before enrollment;

- Life expectancy more than 12 weeks

Exclusion Criteria:

- Pregnant or breast-feeding women or positive serum pregnancy test;

- Uncontrolled brain metastases. Patients with brain metastases must be locally treated
and the disease must be stable for at least one month at the time of enrolling;

- Participation in any investigational drug study within 4 weeks preceding treatment
start;

- Concurrent other malignancy at other sites or previous other cancer within the last 5
years, with the exception of adequately treated in situ carcinoma of cervix uteri or
basal or squamous cell carcinoma of the skin or a contralateral breast cancer;

- Serious uncontrolled intercurrent infections;

- Poor compliance