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The Impact on Postoperative Pain of Substituting Opioids by Beta Blockers for Peroperative Hemodynamic Control in Patients Undergoing Mastectomy


N/A
18 Years
65 Years
Open (Enrolling)
Female
Pain, Postoperative, Breast Cancer, Postoperative Nausea and Vomiting

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Trial Information

The Impact on Postoperative Pain of Substituting Opioids by Beta Blockers for Peroperative Hemodynamic Control in Patients Undergoing Mastectomy


Inclusion Criteria:



- Woman

- 18 to 65 years old

- ASA 1 or 2

- First breast surgery

- Unilateral breast cancer

- Partial mastectomy or radical modified mastectomy ± axillary dissection

Exclusion Criteria:

- Allergy or contrindication to any medication figuring in the protocol or to Aspirin

- Patient taking betablocking drug drug or lanoxin or calcic channels blocking drug

- Narcotic consumption in the past month of 10 mg/day of morphine equivalent

- Chronic pain

- Moderate to severe asthma

- BMI of more than 40

- Diabetes

- Chronic renal or hepatic faiure

- Heart failure

- Anticipated difficult airway

- High grade heart block or bifascicular block

- Mental retardation

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Outcome Measure:

Postoperative consumption of narcotic in recovery room

Outcome Time Frame:

Immediately after surgery

Safety Issue:

No

Principal Investigator

Etienne de Medicis, MD MSc

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre Hospitalier Universitaire de Sherbrooke

Authority:

Canada: Health Canada

Study ID:

CRC-09-174

NCT ID:

NCT01544959

Start Date:

January 2010

Completion Date:

January 2018

Related Keywords:

  • Pain, Postoperative
  • Breast Cancer
  • Postoperative Nausea and Vomiting
  • Narcotic
  • Opioid
  • betablocking drug
  • postoperative pain
  • postoperative nausea and vomiting
  • breast cancer
  • hyperalgesia
  • cancer recurrence
  • anesthesia
  • mastectomy
  • chronic postsurgical pain syndrome
  • acute postoperative pain
  • postmastectomy pain syndrome
  • pain
  • ambulatory surgery
  • Breast Neoplasms
  • Nausea
  • Vomiting
  • Pain, Postoperative
  • Postoperative Nausea and Vomiting

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