Trial Information
The Impact on Postoperative Pain of Substituting Opioids by Beta Blockers for Peroperative Hemodynamic Control in Patients Undergoing Mastectomy
Inclusion Criteria:
- Woman
- 18 to 65 years old
- ASA 1 or 2
- First breast surgery
- Unilateral breast cancer
- Partial mastectomy or radical modified mastectomy ± axillary dissection
Exclusion Criteria:
- Allergy or contrindication to any medication figuring in the protocol or to Aspirin
- Patient taking betablocking drug drug or lanoxin or calcic channels blocking drug
- Narcotic consumption in the past month of 10 mg/day of morphine equivalent
- Chronic pain
- Moderate to severe asthma
- BMI of more than 40
- Diabetes
- Chronic renal or hepatic faiure
- Heart failure
- Anticipated difficult airway
- High grade heart block or bifascicular block
- Mental retardation
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Outcome Measure:
Postoperative consumption of narcotic in recovery room
Outcome Time Frame:
Immediately after surgery
Safety Issue:
No
Principal Investigator
Etienne de Medicis, MD MSc
Investigator Role:
Principal Investigator
Investigator Affiliation:
Centre Hospitalier Universitaire de Sherbrooke
Authority:
Canada: Health Canada
Study ID:
CRC-09-174
NCT ID:
NCT01544959
Start Date:
January 2010
Completion Date:
January 2018
Related Keywords:
- Pain, Postoperative
- Breast Cancer
- Postoperative Nausea and Vomiting
- Narcotic
- Opioid
- betablocking drug
- postoperative pain
- postoperative nausea and vomiting
- breast cancer
- hyperalgesia
- cancer recurrence
- anesthesia
- mastectomy
- chronic postsurgical pain syndrome
- acute postoperative pain
- postmastectomy pain syndrome
- pain
- ambulatory surgery
- Breast Neoplasms
- Nausea
- Vomiting
- Pain, Postoperative
- Postoperative Nausea and Vomiting