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Endogenous DNA Transposition in Rhabdoid Tumors


N/A
N/A
1 Year
Open (Enrolling)
Both
Kidney Cancer

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Trial Information

Endogenous DNA Transposition in Rhabdoid Tumors


OBJECTIVES:

- To investigate the expression and function of PGBD5 in 50 primary rhabdoid tumors.

OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ
hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location
of PGBD5. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Freshly frozen rhabdoid tumors from either renal or extra-renal sites from children
younger than 2 years of age

- Clinical patient information (age, gender, comorbidities, tumor stage, size,
pathology, therapy, outcome) available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Expression and function of PGBD5 in rhabdoid tumors

Safety Issue:

No

Principal Investigator

Elizabeth A. Mullen, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dana-Farber Cancer Institute

Authority:

United States: Federal Government

Study ID:

CDR0000727229

NCT ID:

NCT01544569

Start Date:

March 2012

Completion Date:

Related Keywords:

  • Kidney Cancer
  • rhabdoid tumor of the kidney
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Rhabdoid Tumor

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