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Improving Adherence to Web-Based Cessation Programs: A Social Network Approach

18 Years
Open (Enrolling)
Smoking Cessation

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Trial Information

Improving Adherence to Web-Based Cessation Programs: A Social Network Approach

This study will compare the efficacy of an interactive, evidence-based smoking cessation
website (WEB) alone and in conjunction with 1) a theory-driven, empirically-informed social
network (SN) protocol designed to integrate participants into the online community, and 2)
access to a 4-week supply of free NRT. Using a 2 (SN integration, no SN) x 2 (access to free
NRT, no access) randomized, controlled factorial design with repeated measures at baseline,
3, and 9 months, this study will recruit N=4,000 new members of a Web-based smoking
cessation program and randomize them to: 1) WEB, 2) WEB+SN, 3) WEB+NRT, or 4) WEB+SN+NRT.

Aim 1: To evaluate the comparative efficacy of WEB+SN, WEB+NRT, and WEB+SN+NRT versus WEB
alone with regard to self-reported 30-day point prevalence abstinence at the primary
endpoint of 9 months and at secondary endpoint of 3 months. Hypothesis 1a: All three
intervention conditions will outperform WEB. Hypothesis 1b: WEB+SN+NRT will outperform

Aim 2: To examine whether the impact of treatment condition on cessation is mediated by
greater adherence to problem solving/skills training tools, social support, and
pharmacotherapy. Hypothesis 2: WEB+SN+NRT will have the greatest impact on treatment
adherence, which will yield higher quit rates than the other treatments.

Exploratory Aim: To advance theory and identify the processes through which social network
integration and provision of free NRT influence treatment adherence. Specifically,
exploratory analyses will examine whether social support and social norms are active
elements in the pathway to adherence, along with other known mediators of abstinence such as

Inclusion Criteria:

- Age 18 years and older

- Current smoker

- Registered user on

Exclusion Criteria:

- Pregnant or breastfeeding

- Cardiovascular conditions

- Current use of any stop smoking medication

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Outcome Measure:

Self-reported 30-day point prevalence abstinence

Outcome Description:

In the past 30 days, have you smoked any cigarettes at all, even a puff?

Outcome Time Frame:

9 months post-randomization

Safety Issue:


Principal Investigator

Amanda L Graham, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

American Legacy Foundation


United States: Institutional Review Board

Study ID:




Start Date:

February 2012

Completion Date:

October 2015

Related Keywords:

  • Smoking Cessation
  • Web based behavioral intervention
  • Adherence
  • Smoking cessation
  • Social network
  • Nicotine replacement therapy
  • Social support
  • Smoking



American Legacy Foundation Washington, District of Columbia  20036