Inclusion Criteria:

1. Written informed consent prior to performance of study-specific procedures or
assessments and must be willing to comply with treatment and follow-up.

2. Age ≥ 18 years or legal age of consent if different from 18 years.

3. Histologically confirmed diagnosis of high-risk (G2/3, diameter ≥5 cm) STS of any
location (extremities, girdle, trunk, retroperitoneum).

4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

5. Measurable disease according to RECIST 1.1

6. Resectable and non-metastatic tumor, as assessed by the investigator based on staging
exams (CT scan of the chest, CT or MRI of the abdomen, MRI of the limb in case of
extremity STS).

7. Adequate organ system function

8. Women of childbearing potential must have a negative serum pregnancy test within 14
days of first dose of study treatment and agree to use effective contraception,
during the study and until after surgery has been performed.

9. Female subjects who are lactating should discontinue nursing prior to the first dose
of study drug and should refrain from nursing throughout the treatment period and for
14 days following the last dose of study drug.

Exclusion Criteria:

1. The following tumor types are ineligible

- Embryonal rhabdomyosarcoma

- Chondrosarcoma

- Osteosarcoma

- Ewing tumors / PNET

- Gastro-intestinal stromal tumors

- Dermofibromatosis sarcoma protuberans

- Inflammatory myofibroblastic sarcoma

- Malignant mesothelioma

2. Prior malignancy.

3. History or clinical evidence of central nervous system (CNS) metastases or
leptomeningeal carcinomatosis.

4. Prior or concurrent systemic chemotherapy or molecularly targeted therapy for STS or
other malignancies within five years before study entry.

5. Clinically significant gastrointestinal abnormalities that may increase the risk for
gastrointestinal bleeding.

6. Clinically significant gastrointestinal abnormalities that may affect absorption of
investigational product

7. Corrected QT interval (QTc) > 480 msecs (calculation according to Bazett).

8. Presence of uncontrolled infection.

9. History of any one or more of the following cardiovascular conditions within the past
6 months:

- Cardiac angioplasty or stenting

- Myocardial infarction

- Unstable angina

- Coronary artery bypass graft surgery

- Symptomatic peripheral vascular disease

- Class III or IV congestive heart failure, as defined by the New York Heart
Association (NYHA)

10. Poorly controlled hypertension [defined as systolic blood pressure (SBP) of ≥140 mmHg
or diastolic blood pressure (DBP) of ≥ 90mmHg].

11. Cerebrovascular accident including transient ischemic attack (TIA), pulmonary
embolism or untreated deep venous thrombosis (DVT) within the past 6 months.

12. Major surgery or trauma within 28 days prior to first dose of investigational product
and/or presence of any non-healing wound, fracture, or ulcer (procedures such as
catheter placement are not considered to be major surgery).

13. Evidence of active bleeding or bleeding diathesis.

14. Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that
increase the risk of pulmonary hemorrhage.

15. Recent hemoptysis (more than ½ teaspoon of red blood within 8 weeks before first dose
of study drug).

16. Any serious and/or unstable pre-existing medical, psychiatric, or other condition
that could interfere with subject's safety, provision of informed consent, or
compliance to study procedures.

17. Inability or unwillingness to discontinue use of prohibited medications for at least
14 days or five half-lives of a drug (whichever is longer) prior to the first dose of
investigational product and for the duration of the study.

18. Treatment with any of the following therapies:

- radiation therapy, surgery targeting the lesion under study other than
incisional biopsy, or tumor embolization, prior to the first dose of pazopanib
OR

- chemotherapy, immunotherapy, biologic therapy, antiangiogenic therapy,
investigational therapy or hormonal therapy, targeting the lesion under study,
prior to the first dose of pazopanib OR

- chemotherapy, immunotherapy, biologic therapy, antiangiogenic therapy,
investigational therapy or hormonal therapy, targeting any other lesion /
disease, within 14 days or five half-lives of a drug (whichever is longer) prior
to the first dose of pazopanib

19. Administration of any non-oncologic investigational drug within 30 days or 5 half
lives whichever is longer prior to receiving the first dose of study treatment.

20. Any ongoing toxicity from prior anti-cancer therapy that is > grade 1 and/or that is
progressing in severity, except alopecia.