Inclusion Criteria:

- Female between 18 and 70 years old;

- Patients with histologic proved metastatic breast cancer;

- Pleural effusion with the volume of more than 1000ml, as documented by CT, X ray or
ultrasound;

- There are no other diseases which cause the elevation of IL-6 or IL-8, such as
cirrhosis of liver, anaphylactoid purpura, acute pancreatitis;

- With at least one measurable disease according to RECIST criteria,

- Normal laboratory results:ANC≥2.0×109/L,Hb≥80g/L,plt≥100×109/L,TB patients with liver mets),ALT/AST< 1.5 x UNL (<2.5x UNL in patients with liver
mets),AKP<5 x UNL(except bone mets),Cr
- Normal functions with heart, liver,renal and bone marrow;

- Got ICF before enrollment;

- Life expectancy more than 12 weeks.

Exclusion Criteria:

- Pregnant or breast-feeding women or positive serum pregnancy test;

- Uncontrolled brain metastases;

- No recovery from previous radiation or accepted radiation within 4 weeks before
enrollment;

- Participation in any investigational drug study within 4 weeks preceding treatment
start;

- Concurrent other malignancy at other sites or previous other cancer within the last 5
years, with the exception of adequately treated in situ carcinoma of cervix uteri or
basal or squamous cell carcinoma of the skin;

- Serious uncontrolled intercurrent infections;

- Poor compliance.