Trial Information

Biological Analysis of Ethnic Variations in Wilms Tumor

OBJECTIVES:

- To determine a unique molecular "finger print" of primary Wilms tumor arising in
ethnically diverse children who are at increased risk to develop this lethal malignancy
and subsequently relapse.

- To determine a unique protein "finger print" from the urine of ethnically diverse
children who develop Wilms tumor and subsequent relapse.

OUTLINE: Formalin-fixed paraffin-embedded and snap-frozen primary tissue samples, and urine
samples collected at the time of diagnosis and before treatment, are analyzed for molecular
and protein profile by MALDI-TOF mass spectroscopy, western blotting, immunohistochemistry,
and reverse-transcriptase polymerase chain reaction (RT-PCR) assays.