Inclusion Criteria:

1. Male or Female > 18 years,

2. Newly diagnosed stage I-IV breast cancer which is defined to meets any one of the
following clinical or pathological staging criteria (version 6.0 AJCC
classification17) in Appendix B.

3. No prior therapy (other than surgery) for current disease,

4. Written informed consent (if required by local regulations).

Exclusion Criteria:

1. Unable to receive definitive treatment

2. Unable to attend regular follow-up visit