Inclusion Criteria:

Subjects with:

- Confirmed Advanced Primary Liver Cancer (Hepatocellular Carcinoma: HCC)

- Not having received prior systemic treatment for advanced HCC

- Normal or moderately impaired liver function (Child-Pugh Class A or B (CP total score
of ≤ 7))

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

Exclusion Criteria:

Subjects with:

- Brain metastasis or evidence of leptomeningeal disease

- History of impaired brain function (encephalopathy) or active heart disease

- Unmanageable fluid in the abdomen (ascites)

- Bleeding esophageal or gastric varices within 2 months prior to inclusion