Assessing Serial Tumour Necrosis Factor Release in Locally Advanced Breast Cancer Patients Receiving Neo-adjuvant Taxane Chemotherapy
This pilot study will begin to test the clinical relevance of the TNFa pathway in docetaxel
response in breast cancer patients receiving Taxane chemotherapy.
- Assess whether docetaxel can induce TNFa expression in breast cancer patients being
treated with docetaxel
Interventional
Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
measure tissue TNFa levels
The TNFa levels will be evaluated using ELISA method
18 months
No
Muriel Brackstone, MD
Principal Investigator
Lawson Health Research Institute
Canada: Ethics Review Committee
TNFactor
NCT01539876
April 2013
September 2013
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