Blood Flow MRI for Monitoring of Glioma Angiogenesis
Our goals are:
1. To compare the blood flow measured with this technique with measures of tumor blood
vessel density in pieces of the tumor surgically removed as a normal part of clinical
treatment. This will confirm a relationship between the imaging measurements and the
microscopic characteristics of tumors.
2. To compare the blood flow in tumors before therapy with the concentration of choline,
an indicator of cell proliferation. This choline concentration can be measured with
another MRI technique. This information will demonstrate the relationship between cell
proliferation and blood supply and will also determine whether the choline measurement
adds additional information that is clinically necessary.
3. To determine the reproducibility of blood flow measurements in tumors. This is
necessary to better understand the sensitivity of the technique to changes in flow
caused by a treatment or changes in tumor vascularity.
4. To monitor changes in blood flow after initial treatment. Since sometimes tumors can
reappear, the repeated measures will help determine how useful this new imaging
technique is at detecting such recurring tumors.
Observational Model: Case-Only, Time Perspective: Cross-Sectional
David C Alsop, PhD
Beth Israel Deaconess Medical Center
United States: Institutional Review Board
|Beth Israel Deaconess Medical Center||Boston, Massachusetts 02215|