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Neutrophil Extracellular Traps (NETs) Formation Following Chemotherapy for Pediatric Hematological and Solid Tumors, and Its Relation to Other Neutrophil Functions and the Role of NETs in Antitumor Activity


N/A
N/A
21 Years
Open (Enrolling)
Both
Pediatric Solid Malignancies, Pediatric Hematological Malignancies

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Trial Information

Neutrophil Extracellular Traps (NETs) Formation Following Chemotherapy for Pediatric Hematological and Solid Tumors, and Its Relation to Other Neutrophil Functions and the Role of NETs in Antitumor Activity


Neutrophil function, including NETs formation, chemotaxis, superoxide production, hydrogen
peroxide production, and the presence of myeloperoxidase, will be examined in 50 pediatric
patientsundergoing chemotherapy for solid and hematological malignancies. Children with the
following malignancies will be examined: acute lymphoblastic leukemia,acute myelogenous
leukemia,Hodgkin's lymphoma,non-Hodgkin's lymphoma, primary bone
sarcoma,rhabdomyosarcoma,non-rhabdomyosarcoma,neuroblastoma,Wilms' tumor,hepatoblastoma or
hepatocellular carcinoma,germ cell tumors, and hystiocytosis. Also those with brain tumors
such as medulloblastom,low grade glioma,high grade glioma,ependymoma,and embryonal and
pineal region tumors. Data gathered on the patients will include background data (age,
gender, ethnicity) and background diseases, data on current illness (histologic type, grade,
stage, response treatment,infectious episodes), and on the use of ranulocyte-colony
stimulating factor (G-CSF).

The following time points will be examined:

1. At diagnosis, before initiation of chemotherapy.

2. immediately before the 2nd course.

3. After the middle course.

4. A month after the last course.

5. Three months after the last course.

6. In acute myelogenous leukemia and acute lymphoblastic leukemia,time points also include
the middle of the maintenance course and 3 months after the end of maintenance.

An additional blood examination will be used to examine NETs formation against tumor cell
lines and their ability to kill tumor cells.


Inclusion Criteria:



Included in the study were patients with:

- Acute lymphoblastic leukemia or acute myelogenous leukemia.

- Hodgkin's lymphoma or non-Hodgkin's lymphoma.

- Primary bone sarcoma, rhabdomyosarcoma, non-rhabdomyosarcoma, neuroblastoma, Wilms'
tumor, hepatoblastoma or hepatocellular carcinoma, hystiocytosis, and germ cell
tumors.

- Medulloblastoma, low grade glioma, high grade glioma, ependymoma, and embryonal and
pineal region tumors.

Exclusion Criteria:

- A severe background disease that may affect Neutrophil function (e.g., diabetes,
lupus).

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Sivan Achituv, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

The department of pediatric hemato-oncology, Dana Childrens' Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel

Authority:

Israel: Ministry of Health

Study ID:

0592-11-TLV

NCT ID:

NCT01533779

Start Date:

February 2012

Completion Date:

February 2015

Related Keywords:

  • Pediatric Solid Malignancies
  • Pediatric Hematological Malignancies
  • children
  • malignancy
  • neutrophil
  • neutrophil extracellular traps
  • superoxide production
  • hydrogen peroxide production
  • chemotaxis
  • myeloperoxidase
  • immunosurveillance
  • cancer cell lines
  • Neoplasms
  • Hematologic Neoplasms

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