Inclusion Criteria:

- patients with histologically or cytologically confirmed diagnosis of metastatic
colorectal cancer not amenable to surgery

- Adjuvant treatment ended ≥6 months before the study entry

- No prior exposure to irinotecan and/or bevacizumab in the adjuvant treatment

- No prior exposure to cytotoxic drugs for the metastatic disease

- At least one measurable lesion according to the RECIST criteria

- adequate laboratory parameters (Hemoglobin level ≥ 9.0 g/dL; Neutrophil count > 1.5 x
109/L; Platelets count >100 x 109/L; Total bilirubin <1.5 time the upper-normal
limits (UNL) and ASAT (SGOT) and/or ALAT (SGPT) <2.5 x UNL, or <5 x UNL in case of
liver metastases; alkaline phosphatase <2.5 x UNL, or <5 x UNL in case of liver
metastases; PT-INR/PTT < 1.5 x UNL;Creatinine clearance > 50 mL/min or serum
creatinine <1.5 x UNL; Urine dipstick of proteinuria < 2+)

- Written informed consent.

- Patients must be accessible for treatment and follow up.

Exclusion Criteria:

- Untreated brain metastases or spinal cord compression

- History of inflammatory bowel disease and/or acute or subacute bowel occlusion.

- Serious, non-healing wound, ulcer, or bone fracture

- Evidence of bleeding diathesis or coagulopathy.

- Uncontrolled hypertension.

- Clinically significant cardiovascular disease(cerebrovascular accidents ≤ 6 months,
myocardial infarction ≤ 6 months, unstable angina, New York Heart Association (NYHA)
grade II or greater congestive heart failure, serious cardiac arrhythmia requiring
medication)

- Current or recent (within 10 days prior to study treatment start) ongoing treatment
with anticoagulants for therapeutic purposes.

- Chronic, daily treatment with high-dose aspirin (>325 mg/day) or other medications
known to predispose to gastrointestinal ulceration.

- Treatment with any investigational drug within 30 days prior to enrolment.

- Patients with known allergy to Chinese hamster ovary cell proteins, or any of the
components of the study medications

- Other co-existing malignancies or malignancies diagnosed within the last 5 years with
the exception of basal and squamous cell carcinoma or cervical cancer in situ

- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to study treatment start, or anticipation of the need for major surgical
procedure during the course of the study.

- Pregnant or lactating women. Women of childbearing potential with either a positive
or no pregnancy test at baseline

- Substance abuse, medical, psychological or social conditions that may interfere with
the participation into the study or the evaluation of study results

- Patients unable to swallow oral medications