Metformin Versus Metfotmin Plus Low-dose Spironolactone in the Treatment of Overweight/Obese Patients With Polycystic Ovary Syndrome: a Randomized Study
In the present prospective, randomized study, we evaluated the efficacy of a combined
therapy with metformin and low-dose spironolactone as compared to metformin alone on the
clinical and endocrine-metabolic alterations of PCOS patients.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Metformin versus Metformin plus low-dose Spironolactone on metabolic parameters of Patients with Polycystic Ovary Syndrome: a randomized study
We evaluated metabolic parameters across anthropometric parameters: height, weight, waist circumference, BMI, glycemia, lipid profile, blood count, coagulation parameters, hepatic and renal function indexes, OGTT and HOMA-IR. The diagnosis of MetS was established according to the ATPIII criteria
six months
No
A. Mazza B. Fruci A. Belfiore, Doctors
Principal Investigator
Endocrinology Unit
Italy: Ethics Committee
2010.31
NCT01526616
May 2010
July 2011
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