High Dose Chemotherapy and Autologous Peripheral Blood Stem Cell (PBSC) Rescue for Neuroblastoma: Standard of Care Considerations
This therapy involves the use of melphalan, etoposide, and carboplatin (consolidation
chemotherapy); autologous stem cell rescue, post-transplant radiation therapy and a
maintenance phase with Isotretinoin (Accutane, 13-cis-retinoic acid) therapy. If available,
patients should also consider post-transplant therapy with cytokines and monoclonal antibody
(ch14.18) on a COG or New Approaches to Neuroblastoma Therapy (NANT) trial.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Number of Patients with Successful Engraftment
The time to neutrophil engraftment will be assessed by standard statistical approaches.
Michael R. Verneris, M.D.
Masonic Cancer Center, University of Minnesota
United States: Institutional Review Board
|Masonic Cancer Center, University of Minnesota||Minneapolis, Minnesota 55455|