Inclusion Criteria:

- Symptomatic multiple myeloma of any subtype in any disease stage, providing that
patient does not have smoldering myeloma.

- Patient must otherwise be a candidate for ASCT as determined by treating physician.

- No current CNS Myeloma at time of enrollment.

- Life expectancy greater than 12 weeks.

- Age greater than or equal to 21 and less than or equal to 70 years old.

- EGOG performance status less than or equal to 2.

- No cardiac, pulmonary, hepatic, or renal contraindications for high dose
chemotherapy.

- HIV Negative.

- No active Hepatitis B or C.

- Patients must be able to provide written informed, consent.

Exclusion Criteria:

- Pregnant or nursing women. Women of child-bearing age must be tested for pregnancy.

- Use of systemic immunosuppressive medications, including corticosteroids, tacrolimus,
mycophenolate mofetil, sirolimus or cyclosporine A.

- Psychiatric illness which may make compliance to the clinical protocol unmanageable
or which may compromise the ability of the patient to give informed consent.

- Active autoimmune disease including but not limited to: rheumatoid arthritis
inflammatory bowel disease, celiac disease, systemic lupus erythematosis, scleroderma
or multiple sclerosis.