Inclusion Criteria:

- Signed written informed consent

- Male or female >= 18 years of age

- Diagnosis of histologically confirmed, KRAS "wild-type" adenocarcinoma of the colon
or rectum

- Non-resectable metastatic colorectal carcinoma

- Either presence of at least one liver lesion measurable unidimensionally by CT scan
or MRI or at least one resectable liver metastasis with non-resectable extrahepatic
disease (as assessed within 3 weeks prior to randomisation)

- Subjects scheduled to receive cetuximab and FOLFIRI

- ECOG performance status of 0 - 1 at study entry

- Leukocytes >= 3.0 x 10^9/L and neutrophils >= 1.5 x 10^9/L, platelets >= 100 x
10^9/L, and hemoglobin >= 8 g/dL

- Bilirubin <= 1.5 x ULN

- ASAT and ALAT <= 5 x ULN

Exclusion Criteria:

- Brain metastasis (if suspected, brain scan indicated)

- Previous chemotherapy for the currently existing metastatic disease

- Known or newly diagnosed diabetes

- Patients with ACS within the last three months

- Stage 3 or 4 heart failure defined according to the NYHA criteria

- Uncontrolled angina

- Contraindications to metformin (renal impairment [eGFR <45 mL/min/1.73m^2], known
hypersensitivity to metformin, acute illness [dehydration, severe infection, shock,
acute cardiac failure]), and suspected tissue hypoxia

- Surgery (excl. diagnostic biopsy, central venous catheter) or irradiation within 2
weeks prior to study entry defined as given written informed consent

- Concurrent chronic systemic immune therapy, chemotherapy, or hormone therapy not
indicated in the study protocol

- Administration of any investigational agent(s) within 4 weeks prior to study entry,

- Previous exposure to EGFR-pathway targeting therapy

- Acute or sub-acute intestinal occlusion or history of inflammatory bowel disease

- Known grade 3 or 4 allergic reaction to any of the components of the treatment

- Any concurrent malignancy other than non-melanoma skin cancer, or carcinoma in situ
of the cervix. (Subjects with a previous malignancy but without evidence of disease
for >= 5 years will be allowed to enter the trial)

- Pregnancy or lactation

- Inadequate contraception (male or female patients) if of childbearing or procreative
potential

- Known drug abuse/ alcohol abuse

- Legal incapacity or limited contractual capacity Medical or psychological condition
which in the opinion of the investigator would not permit the patient to complete the
study or sign meaningful informed consent