Signaling in Tumorigenesis and Immunity
OBJECTIVES:
- To test whether the tumor suppressor candidate gene PDLIM2 is downregulated in human
cancers such as T-cell acute lymphoblastic leukemia (T-ALL) and to use the human
T-lymphotropic virus 1 (HTLV-1)-mediated in vitro transformation of human T cells as
control.
OUTLINE: Previously collected cancer and control tissues are analyzed for the expression
patterns of PDLIM2 and other control genes. Human T-cells isolated from human blood are also
co-cultured with HTLV-1-transformed T-cell lines.
Observational
N/A
PDLIM2 expression patterns in cancer and control tissues
No
Gutian Xiao, MD
Principal Investigator
University of Pittsburgh
United States: Federal Government
CDR0000723902
NCT01520246
January 2012
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