Inclusion Criteria:

- Informed consent form

- Histologically confirmed locally advanced (stages III and IVb), squamous cell
carcinoma of the oropharynx and hypopharynx

- The tumor mass had to be measurable

- Karnofsky performance status ≥70

- Life expectancy estimated than 6 months

- Hematologic: WBC≥4×109 /L , plateletes≥100×109 /L, haemoglobin ≥100 g/L；

- Hepatic: AST/ALT＜1.5 times upper limit of normal (ULN)；serum bilirubin<1.5 times ULN;

- Renal: Creatinine＜1.5 times ULN；

Exclusion Criteria:

- Known distant metastases

- Primary tumor and nodes received surgery(except of biopsy)

- Received other anti EGFR monoclonal antibody treatment

- Previous chemotherapy or radiotherapy

- Participation in other interventional clinical trials within 1 month

- Other malignant tumor (except of non-melanoma skin Cancer or carcinoma in situ of
cervix)

- History of serious allergic or allergy

- History of Serious lung or heart disease

- Pregnancy or lactation women, or women with suspected pregnancy or men with willing
to get pregnant