Effect of Curcumin on Lung Inflammation
N/A
40 Years
80 Years
40 Years
80 Years
Not Enrolling
Both
Chronic Obstructive Pulmonary Disease
Both
Chronic Obstructive Pulmonary Disease
Trial Information
Effect of Curcumin on Lung Inflammation
Inclusion Criteria:
- Age equal or more than 45 with moderate COPD: FEV1/FVC ratio less than 70 percent;
post bronchodilator FEV1 less than 50 percent
- 20 pack year cigarette smoking
- Stable clinical course (symptoms/ medications) for 8 weeks
- Fixed address/Not planning to leave
- Being able to perform spirometry
- Able to understand and consent
Exclusion Criteria:
- Other chronic respiratory diseases such as asthma, interstitial fibrosis, sarcoidosis
- Heart failure NYH III & IV; symptomatic liver or renal failure
- Dementia or other neurocognitive deficit preventing completion of symptom diary
- Use of inhaled or systemic corticosteroids within 8 weeks of enrollment in the study
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Outcome Measure:
Change in sputum dysplasia
Outcome Description:
We evaluated presence of moderate or worse dysplasia at baseline and each subsequent visits. The primary endpoint of this study is change in sputum cytological abnormality (moderate or worse dysplasia). The change will be comparison of 3-month follow up compared to baseline.
Outcome Time Frame:
3 months
Safety Issue:
No
Authority:
United States: Institutional Review Board
Study ID:
H-17419
NCT ID:
NCT01514266
Start Date:
April 2005
Completion Date:
August 2010
Related Keywords:
- Chronic Obstructive Pulmonary Disease
- proven diagnosis
- COPD
- sputum
- Inflammation
- Lung Diseases
- Respiration Disorders
- Pulmonary Disease, Chronic Obstructive
- Pneumonia
- Lung Diseases, Obstructive
Name | Location |
|---|---|
| VA Medical Center | Houston, Texas 77030 |
