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Effect of Curcumin on Lung Inflammation


N/A
40 Years
80 Years
Not Enrolling
Both
Chronic Obstructive Pulmonary Disease

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Trial Information

Effect of Curcumin on Lung Inflammation


Inclusion Criteria:



- Age equal or more than 45 with moderate COPD: FEV1/FVC ratio less than 70 percent;
post bronchodilator FEV1 less than 50 percent

- 20 pack year cigarette smoking

- Stable clinical course (symptoms/ medications) for 8 weeks

- Fixed address/Not planning to leave

- Being able to perform spirometry

- Able to understand and consent

Exclusion Criteria:

- Other chronic respiratory diseases such as asthma, interstitial fibrosis, sarcoidosis

- Heart failure NYH III & IV; symptomatic liver or renal failure

- Dementia or other neurocognitive deficit preventing completion of symptom diary

- Use of inhaled or systemic corticosteroids within 8 weeks of enrollment in the study

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Outcome Measure:

Change in sputum dysplasia

Outcome Description:

We evaluated presence of moderate or worse dysplasia at baseline and each subsequent visits. The primary endpoint of this study is change in sputum cytological abnormality (moderate or worse dysplasia). The change will be comparison of 3-month follow up compared to baseline.

Outcome Time Frame:

3 months

Safety Issue:

No

Authority:

United States: Institutional Review Board

Study ID:

H-17419

NCT ID:

NCT01514266

Start Date:

April 2005

Completion Date:

August 2010

Related Keywords:

  • Chronic Obstructive Pulmonary Disease
  • proven diagnosis
  • COPD
  • sputum
  • Inflammation
  • Lung Diseases
  • Respiration Disorders
  • Pulmonary Disease, Chronic Obstructive
  • Pneumonia
  • Lung Diseases, Obstructive

Name

Location

VA Medical CenterHouston, Texas  77030