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Evaluation of PI3K/AKT/mTOR Signaling Pathway Using BKM120 or BEZ235 in Early Breast Cancer

Phase 0
18 Years
Open (Enrolling)
Breast Cancer

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Trial Information

Evaluation of PI3K/AKT/mTOR Signaling Pathway Using BKM120 or BEZ235 in Early Breast Cancer

BKM120 is a potent and highly specific oral pan-class I phosphatidylinositol-3-kinase (PI3K)
inhibitor, currently under investigation in a first-in-man study in patients with advanced
solid tumors (wild type and PIK3CA-mutated). Consistent, dose-dependent pharmacodynamic
activity has been demonstrated and clear signs of anti-tumor activity have been seen with
BKM120. Three breast cancer patients showed significant tumor shrinkage after ≥ 2 months.
Two confirmed partial responses (PRs) per RECIST have been seen, one in a patient with a
triple negative KRAS-mutated breast cancer and the other in a patient with an estrogen
receptor (ER)-positive, PIK3CAmutated tumor. Two minor responses have also been observed;
one of these occurred in a HER2+/ER+ breast cancer patient.

BEZ235 is a pan-class I PI3K and mTORC1/C2 inhibitor under investigation in a first-in-man
study. Clinical data shows that BEZ235 treatment is well tolerated, induces dose-dependent
pathway inhibition in tissues, and results in anti-tumor activity, particularly in patients
with PI3K pathway deregulated cancers. Three PRs have been observed, one in a patient with
PTEN-mutated, metastatic non small-cell lung carcinoma (NSCLC), one in a patient with
metastatic ER+ breast cancer (mutational status unknown), and another in a patient with
HER2+, PIK3CA-mutated, metastatic breast cancer. In a significant number of patients
(14/59), disease has been stabilized by four up to more than twelve months.

Inclusion Criteria:

- Age ≥ 18 years

- ER+ / HER2 negative breast cancer patients

- WHO performance status £ 2

- Previously untreated histologically confirmed invasive, non-metastatic, breast
carcinoma with a tumor size ≥ 1,5cm and non urgent surgical treatment

- Activated Pi3K pathway in breast cancer trucut biopsy

- Documentation of negative pregnancy test for patients of child bearing potential
within 7 days prior to start study treatment. Sexually active pre-menopausal patients
must use adequate contraceptive measures, excluding estrogen containing
contraceptives, while on study.

- Patients must meet the following laboratory criteria within 7 days prior to start the
study treatment:

- Hematology

- Neutrophil count of > 1200/mm3

- Platelet count of > 100,000/ mm3

- Hemoglobin > 90g/L

- Biochemistry

- AST/SGOT and ALT/SGPT < 2.5 x upper limit of normal (ULN) or < 5.0 x ULN if the
transaminase elevation is due to liver metastases

- Total bilirubin < 1.5 x ULN [Patients with Gilbert Syndrome must have total bilirubin
< 3 ULN]

- Cholesterol < ULN - 7.75 mmol/L and Triglycerides < ULN - 2.5 x ULN (with
lipid-lowering drugs permitted)

- Serum creatinine < 1.5 x ULN or 24-hour creatinine clearance > 60 mL/min

- Serum albumin > LLN or > 30 g/L

- Fasting plasma glucose ≤ 140 mg/dL (7.8 mmol/L)

Exclusion Criteria:

- Patients who have received prior treatment with a P13K inhibitor

- Patients with a known hypersensitivity to BEZ235 or BKM120 or to its excipients

- Patients with a history of photosensitivity reactions to other drugs

- Patients with the following mood disorders as judged by the Investigator or a
psychiatrist, or as result of patient's mood assessment questionnaire:

- Medically documented history of or active major depressive episode, bipolar disorder
(I or II), obsessive-compulsive disorder, schizophrenia, a history of suicidal
attempt or ideation, or homicidal ideation (immediate risk of doing harm to others)

- ≥ CTCAE grade 3 anxiety The psychiatric judgment overrules the mood assessment
questionnaire result/investigators judgment.

- Impairment of gastrointestinal (GI) function or GI disease that may significantly
alter the absorption of BEZ235 or BKM120 (e.g., ulcerative diseases, uncontrolled
nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection).
Patients with unresolved diarrhea will be excluded as previously indicated

- Patients with diabetes mellitus requiring insulin treatment, history of gestational
diabetes mellitus

- Impaired cardiac function or clinically significant cardiac diseases

- LVEF < 45% as determined by MUGA scan or ECHO

- Complete left bundle branch block

- ST depression or elevation of ≥ 1.5 mm in 2 or more leads

- Congenital long QT syndrome

- History or presence of ventricular arrhythmias or atrial fibrillation

- Clinically significant resting bradycardia (< 50 beats per minute)

- QTc > 460 msec on screening ECG

- Right bundle branch block + left anterior hemiblock (bifascicular block)

- Unstable angina pectoris ≤ 3 months prior to starting the study drug

- Acute myocardial infarction ≤ 3 months prior to starting the study drug

- Other clinically significant heart disease such as congestive heart failure requiring
treatment or uncontrolled hypertension

- Patients who have been treated with any hematopoietic colony-stimulating growth
factors (e.g., G-CSF, GM-CSF) ≤ 2 weeks prior to starting study drug. Erythropoietin
or darbepoetin therapy, if initiated before enrollment, may be continued

- Patients who are currently receiving treatment with medication that has the potential
to prolong the QT interval or inducing Torsades de Pointes and the treatment cannot
either be discontinued or switched to a different medication prior to starting study

- Patients who are currently receiving treatment with therapeutic doses of warfarin
sodium (Coumadin®)

- Patients with known coagulopathies

- Patients who have received chemotherapy, immunotherapy (except for trastuzumab) or
investigational drugs ≤ 4 weeks prior to starting study drug or who have not
recovered from side effects of such therapy

- Patients who have received any continuous-dosing (i.e. daily dosing, ever-other-day
dosing, Monday-Wednesday-Friday dosing weekly etc) therapeutic modalities or
investigational drug (excluding monoclonal antibodies) ≤ 5 half lives prior to
starting study drug or who have not recovered from side effects of such therapy

- Patients who have received corticosteroids ≤ 2 weeks prior to starting study drug or
who have not recovered from the side effects of corticosteroid treatment

- Patients who have received wide field radiotherapy ≤ 4 weeks or limited field
radiation for palliation ≤ 2 weeks prior to starting study drug or who have not
recovered from side effects of such therapy.

- Patients who have undergone major surgery ≤ 2 weeks prior to starting study drug or
who have not recovered from side effects of such therapy

- Women of child-bearing potential who are pregnant or breast feeding and adults of
reproductive potential not employing an effective method of birth control. Adequate
contraception must be used throughout the trial and for 8 weeks after the last dose
of study drug, by both sexes. Women of child-bearing potential must have a negative
serum pregnancy test ≤ 7 days prior to starting BEZ235 or BKM120

- Male patients whose sexual partner(s) are WOCBP who are not willing to use adequate
contraception, during the study and for 8 weeks after the end of treatment

- Patients with a known diagnosis of human immunodeficiency virus (HIV) infection (HIV
testing is not mandatory)

- Patients with a history of another primary malignancy that is currently clinically
significant, has potential for metastases or currently requires active intervention

- Patients who have any severe and/or uncontrolled medical conditions or other
conditions that could affect their participation in the study such as:

- Patients with any other concurrent severe and/or uncontrolled concomitant medical
conditions (e.g. active or uncontrolled infection) that could cause unacceptable
safety risks or compromise compliance with the protocol

- History of noncompliance to medical regimens

- Patients unwilling to or unable to comply with the protocol

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label

Outcome Measure:

- To determine the grade of inhibition of PI3K/mTOR pathways, in pre-surgery setting with BKM120 and BEZ 235 and BEZ235

Outcome Description:

Biomarkers assessments must be performed at baseline and at the end of study treatment. The following biomarkers will be assessed: PI3K, PTEN, Akt, pAkt, ERK-1, PERK-1 and p53.

Outcome Time Frame:

28 days

Safety Issue:



Spain: Spanish Agency of Medicines

Study ID:




Start Date:

October 2012

Completion Date:

February 2014

Related Keywords:

  • Breast Cancer
  • breast
  • cancer
  • CBKM120
  • BEZ235
  • Breast Neoplasms