Analysis of MicroRNA Expression in Down Syndrome Acute Myeloid Leukemia and the Transient Myeloproliferative Disorder
N/A
3 Years
Both
Leukemia
Trial Information
Analysis of MicroRNA Expression in Down Syndrome Acute Myeloid Leukemia and the Transient Myeloproliferative Disorder
OBJECTIVES:
- To compare miRNA expression in distinctive diagnostic groups: transient
myeloproliferative disorder (TMD), Down syndrome (DS) acute megakaryocytic leukemia
(AMkL), non-DS AMkL, and in remission DS samples (representing germline, non-malignant
samples).
OUTLINE: Archived RNA samples are analyzed for mature micro (mi)RNA expression by real-time
RT-PCR. Results are then compared with miRNA expression of non-Down syndrome patients with
acute megakaryocytic leukemia.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Patients with Down syndrome (DS) diagnosed with acute myeloid leukemia or transient
myeloproliferative disorder
- Clinical samples obtained from patients enrolled on the COG AAML0431 and COG AAML08B1
PATIENT CHARACTERISTICS:
- Previously consented to biologic studies
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Gene expression levels between DS AMKL and non-DS AMKL patients
Safety Issue:
No
Principal Investigator
Jeffrey Taub, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Children's Hospital of Michigan
Authority:
United States: Federal Government
Study ID:
CDR0000722054
NCT ID:
NCT01511575
Start Date:
February 2012
Completion Date:
Related Keywords:
- Leukemia
- childhood acute myeloid leukemia in remission
- childhood acute myeloid leukemia/other myeloid malignancies
- childhood acute megakaryocytic leukemia (M7)
- Down Syndrome
- Leukemia
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid
- Myeloproliferative Disorders
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