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Prophylactic Central Neck Dissection for Papillary Thyroid Cancer

18 Years
Not Enrolling
Papillary Thyroid Cancer

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Trial Information

Prophylactic Central Neck Dissection for Papillary Thyroid Cancer

Several respected organizations have recently recommended that total thyroidectomy plus
prophylactic central neck dissection should be the standard operation for papillary thyroid
cancer. However, it is still unclear if this approach has any benefit on survival or
locoregional control of the disease. In addition, potential advantages of this more
aggressive surgical approach should outweigh the risk of morbidity. The purpose of this
retrospective cohort study is to determine whether prophylactic central neck dissection is
beneficial for patients with papillary thyroid cancer staged preoperatively as node
negative. In this study outcomes of total thyroidectomy versus this plus prophylactic
central neck dissection for papillary thyroid cancer are compared in a 10-year follow-up.
Patients operated between 1993 and 1997 (n=282) underwent total thyroidectomy alone, whereas
patients operated between 1998 and 2002 (n=358) underwent total thyroidectomy plus
prophylactic central neck dissection.

Inclusion Criteria:

- a pathological diagnosis of papillary thyroid cancer,

- in a patient with negative cervical lymph nodes on pre-, or intraoperative evaluation

Exclusion Criteria:

- incidental diagnosis of papillary thyroid cancer following hemithyroidectomy and
requiring completion thyroidectomy,

- one-stage lymph nodes dissection based on therapeutic intent,

- previous thyroid surgery,

- incomplete follow-up information,

- incomplete histopathology report,

- ASA grade higher than 3 (American Society of Anesthesiology)

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

overall survival

Outcome Time Frame:

up to 10 years

Safety Issue:


Principal Investigator

Marcin Barczynski, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Jagiellonian University, Medical College


Poland: Ministry of Health

Study ID:




Start Date:

January 1993

Completion Date:

December 2011

Related Keywords:

  • Papillary Thyroid Cancer
  • papillary thyroid cancer
  • central neck dissection
  • survival
  • locoregional control
  • morbidity
  • Thyroid Neoplasms
  • Thyroid Diseases