Prophylactic Central Neck Dissection for Papillary Thyroid Cancer
Several respected organizations have recently recommended that total thyroidectomy plus
prophylactic central neck dissection should be the standard operation for papillary thyroid
cancer. However, it is still unclear if this approach has any benefit on survival or
locoregional control of the disease. In addition, potential advantages of this more
aggressive surgical approach should outweigh the risk of morbidity. The purpose of this
retrospective cohort study is to determine whether prophylactic central neck dissection is
beneficial for patients with papillary thyroid cancer staged preoperatively as node
negative. In this study outcomes of total thyroidectomy versus this plus prophylactic
central neck dissection for papillary thyroid cancer are compared in a 10-year follow-up.
Patients operated between 1993 and 1997 (n=282) underwent total thyroidectomy alone, whereas
patients operated between 1998 and 2002 (n=358) underwent total thyroidectomy plus
prophylactic central neck dissection.
Interventional
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
overall survival
up to 10 years
No
Marcin Barczynski, MD, PhD
Principal Investigator
Jagiellonian University, Medical College
Poland: Ministry of Health
BBN/501/ZKL/1447
NCT01510002
January 1993
December 2011
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