Inclusion Criteria:

- Patients over the age of 18

- Informed consent

- Patients who had a definitive diagnosis of Crohn's disease for more than 6 months
(documented by the standard clinical, radiographic, endoscopic, and histopathologic
criteria)

Exclusion Criteria:

- Hypersensitivity to any component of the pneumococcal vaccine

- Known allergy to pneumococcal vaccination

- Patients who treated with glucocorticoids (prednisolone > 20 mg/day equivalent for 2
weeks or more, and within 3 months of stopping

- Patients who inoculate another vaccine in the past 4 weeks

- Significant protein calorie malnutrition

- Current signs or symptoms of severe, progressive or uncontrolled renal, hepatic,
hematologic, endocrine, pulmonary, cardiac, infectious, neurologic or cerebral
disease

- Any condition which, in the opinion of the Investigator, places the patient at
unacceptable risk if he/she were to participate in the study