Inclusion Criteria:

1. Subjects must have a confirmed solid tumor that is metastatic, unresectable or
recurrent and for which standard curative or palliative measures do not exist or are
no longer effective.

2. Prior and concurrent therapy:

Chemotherapy: At least four weeks since prior cytotoxic chemotherapy or 6 weeks since
nitrosoureas or mitomycin.

Molecular targeted agents including monoclonal antibodies and tyrosine kinase
inhibitors: At least two weeks since last therapy.

Endocrine therapy: Subject may be remain on LHRH antagonist therapy for prostate
cancer if tumor progression has been confirmed.

Radiotherapy: At least 3 weeks since most recent radiotherapy. Other investigational
therapy: At least four weeks since any other investigational therapy.

Concurrent therapy: No other concurrent anticancer or investigational therapy
permitted except as noted above.

3. Measurable disease is not required, but will be evaluated in each subject when
possible.

4. Age ≥18 years

5. ECOG performance status ≤ 1

6. Life expectancy ≥ three months.

7. Central venous access, such as a Portacath or Hickman Line.

8. Pretreatment clinical laboratory parameters within 14 days

9. Availability of 10 unstained slides or paraffin-embedded tissue block from archived
tumor specimen.

10. Subjects must be recovered from any toxicity related to prior anti-neoplastic therapy
(to grade <1). Patients with CTCAE grade 2 or less sensory neuropathy or any grade
alopecia are eligible.

Exclusion Criteria:

1. Subjects who have had cytotoxic chemotherapy or treatment with monoclonal antibodies
within 4 weeks, radiotherapy within 3 weeks, or other molecular targeted therapies.

2. Subjects may not be receiving any other investigational agents.

3. Subjects with known untreated brain metastases. Subjects with known, treated brain
metastases must be stable with no symptoms for four weeks.

4. Subjects receiving enzyme-inducing antiseizure drugs ("EIASD").

5. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, significant pulmonary disease (shortness of breath at rest or mild
exertion), uncontrolled infection or psychiatric illness/social situations that would
limit compliance with study requirements.

6. Pregnant women and breastfeeding should be discontinued.

7. Absence of central venous access for administration of the study drug.