Inclusion Criteria:

- Women between the ages of 30 and 79.

- Untreated stage 1 - 3 invasive breast cancer or a woman never diagnosed with breast
cancer.

- BI-RADS 1, 2, or 3 breast imaging within 12 months for women >40 years of age
recruited into the control group.

Exclusion Criteria:

- <30 or >80 years of age

- Unable to provide informed consent

- Presence of an undefined palpable or mammographic breast lesion suspicious for
malignancy (BIRADS 4 or 5)

- Breast implants

- Bilateral prophylactic mastectomy

- Any prior breasts irradiation

- Any systemic chemotherapy in the past

- Performance status that restricted normal activity for a significant portion of the
day

- Use of luteinizing-hormone-releasing-hormone (LHRH) analogs, prolactin inhibitors,
antiandrogens, or systemic glucocorticoids within three months

- Ever use of tamoxifen, raloxifene, or other SERMs

- Ever use of aromatase inhibitors

- Pregnancy or lactation within six months

- Bleeding diathesis of any kind

1. Inherited coagulation disorder

2. Current coumadin use

3. Use of drugs that inhibit platelet aggregation within 10 days