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Endometrial Receptivity After GnRH Agonist Triggering From Final Oocyte Maturation

Phase 4
18 Years
35 Years
Open (Enrolling)
Ovarian Hyperstimulation Syndrome

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Trial Information

Endometrial Receptivity After GnRH Agonist Triggering From Final Oocyte Maturation

Inclusion Criteria

Inclusion criteria :

- Healthy oocyte donor women

- Aged 18-35 years

- With a menstrual cycle length of 26-35 days

- Normal ultrasound scan of uterus and ovaries

- Normal basal hormones

- No contraindication for controlled ovarian stimulation (COS)

- Willing to participate in the study and providing written informed consent.

Exclusion Criteria:

- Subjects with current or previous history of an endocrine abnormality

- Subjects with an abnormal outcome of blood biochemistry or hematology

- Subjects with an abnormal cervical smear

- Subjects with a chronic disease

- Subjects with any relevant ovarian-, tubal- or uterine-pathology that could
interfere with the COS treatment

- Pregnancy

- Subjects who had a previous history of ovarian hyperresponse or ovarian
hyperstimulation syndrome (OHSS), polycystic ovary syndrome (PCOS) or a basal antral
follicle count (AFC) of more than 20 on ultrasound (11 mm, both ovaries combined) .

- Previous low ovarian response to FSH or hMG treatment (i.e. cycle cancelled due to
insufficient ovarian response or less than 6 oocytes obtained).

- A history of recurrent miscarriage,

- Smoking more than 10 cigarettes per day.

- Not willing to comply with study procedures

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Outcome Measure:

endometrial receptivity gene expression profile

Outcome Time Frame:

participants will be followed for the duration of the cycle, an expected average of 4 weeks

Safety Issue:



Spain: Ethics Committee

Study ID:




Start Date:

November 2011

Completion Date:

Related Keywords:

  • Ovarian Hyperstimulation Syndrome
  • endometrial receptivity
  • gene arrays
  • agonist triggering
  • Endometrial gene expression
  • OHSS
  • Ovarian Hyperstimulation Syndrome
  • Adenoma