Inclusion Criteria:

- adult patients with refractory or relapse acute leukemia not in remission after 2
cecles of induction chemotherapy early relapse (ist remission less than 6 months) not
in remission after 1 cycle of reinduction chgemotherapy multipel relapse patient with
very high-risk cytogenetics in any remission

- age 18-55 years

- with inform consent

- no contraindication for allogeneic transplantation: active infection, allergy to
FLu/Bu/CTX, liver and renal function damage

- HLA matched related (6/6) or unrelated donors (at least 8/10)

Exclusion Criteria:

- age less than 18 years or over 56 years

- HLA mismatched related donor

- liver function/renal function damage (over 2 X upper normal range)

- with mental disease