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Proposed Studies on the Role of Growth Factor Receptor Trafficking in Neuroblastoma Pathogenesis


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Neuroblastoma

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Trial Information

Proposed Studies on the Role of Growth Factor Receptor Trafficking in Neuroblastoma Pathogenesis


OBJECTIVES:

- To determine the expression of UBE4B, hrs, and members of the ubiquitination protein
complex in previously banked primary neuroblastoma tumor samples from the Children's
Oncology Group.

- To determine the correlation of expression levels and cellular localization of the
UBE4B and hrs proteins with growth factor-receptor tumor cell-surface expression.

- To determine the 1p36 deletion status by fluorescence in situ hybridization (FISH)
analysis and their association with expression levels of UBE4B and hrs in previously
banked primary neuroblastoma tumor samples from the Children's Oncology Group.

OUTLINE: Banked tumor tissue samples are analyzed for expression of UBE4B, hrs, members of
the ubiquitination protein complex, growth factor receptors, and 1p36 deletion status by
immunohistochemistry (IHC), fluorescent microscopy, and fluorescence in situ hybridization
(FISH).

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Tumor tissue microarrays from the Children's Oncology Group neuroblastoma tumor bank

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Expression of UBE4B, hrs, and members of the ubiquitination protein complex

Safety Issue:

No

Principal Investigator

Peter Zage, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Texas Children's Cancer Center

Authority:

United States: Federal Government

Study ID:

CDR0000719951

NCT ID:

NCT01493830

Start Date:

December 2011

Completion Date:

Related Keywords:

  • Neuroblastoma
  • neuroblastoma
  • Neuroblastoma

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