Inclusion Criteria:

1. age ≥ 18

2. histologically confirmed adenocarcinoma of colon

3. documented ovarian metastasis in CT or MRI or PET-CT

4. advanced (stage IV), metastatic, or recurrent

5. ECOG performance status of 0~2

6. adequate marrow, hepatic, renal and cardiac functions

7. no prior surgical treatment to ovary

8. provision of a signed written informed consent

Exclusion Criteria:

1. patient who refuses oophorectomy

2. medical condition in which surgery cannot be tolerated Any waiver of these inclusion
and exclusion criteria must be approved by the investigator on a case-by case basis
prior to enrolling the subject. This must be documented by the investigator. No
subject will be allowed to enroll in this study more than once.