Prophylactic Oophorectomy Followed by Chemotherapy Versus Chemotherapy Alone in Colorectal Patients With or Without Ovarian Metastasis
A recent study demonstrated that colorectal cancer with ovarian metastases were less
responsive to chemotherapy compared to extraovarian metastases. The survival impact of
oophorectomy has not been defined yet in this clinical setting. The incidence of
microscopic ovarian metastasis has been reported to be approximately 10%. Therefore, the
investigators propose a prospective study of oophorectomy followed by standard chemotherapy
versus standard chemotherapy alone to determine whether oophorectomy increases survival.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Won-Suk Lee, M.D.
Gachon Univ. GIl Hospital
Korea: Institutional Review Board