Comparative Microarray Analysis of microRNA Expression Profiles in Primary Cutaneous Malignant Melanoma, Cutaneous Malignant Melanoma Metastases and Benign Melanocytic Naevi
Perturbations in microRNA (miRNA) expression profiles has been reported for cutaneous
malignant melanoma (CMM). With regards to a rapidly growing number of newly discovered miRNA
sequences, the availability of up-to-date miRNA expression profiles for primary cutaneous
malignant melanoma (PCMM), cutaneous malignant melanoma metastases (CMMM) and benign
melanocytic naevi (BMN) is limited. Patients with PCMM, CMMM and BMN are included in the
study to perform an exploratory analysis by miRNA expression profiling using microarrays.
Expression levels of miRNA candidates will be validated by TaqMan real-time quantitative
polymerase chain reaction (RT-PCR).
Observational Model: Cohort, Time Perspective: Prospective
Falk G Bechara, PD Dr.
Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum
Germany: Ethics Commission