Prediction of Chemotherapy Response and Patient Prognosis in Non-small Cell Lung Cancer: Dynamic Contrast-enhanced MRI and Diffusion-weighted Imaging Versus Volume-based Parameter of 18F-FDG PET
Study cohort will undergo PET/CT and MRI scans prior to chemotherapy and after the first
chemotherapy cycle. MRI scans include DCE-MRI and DWI. The following parameters will be
calculated using these values:
1. Metabolic parameters on FDG-PET A. SUV change ratio (SCR) = SUVpost/SUVpre B. MTV
change ratio (VCR) = MTVpost/pre C. TLG change ratio = SCR X VCR
2. Perfusion parameters on DCE-MRI A. Kep B. K-trans C. ve
3. Diffusion parameters on DWI A. Mean ADC B. fDM
Observational Model: Case-Only, Time Perspective: Prospective
DWI, DCE-MRI, and FDG PET as early predictor for response and prognosis
The primary endpoint of this study is the prediction of one-year overall survival by monitoring the metabolic and functional responses of the tumor following one cycle of chemotherapy.
Ho Yun Lee, Dr.
Samsung Medical Center
South Korea: Institutional Review Board