Prediction of Chemotherapy Response and Patient Prognosis in Non-small Cell Lung Cancer: Dynamic Contrast-enhanced MRI and Diffusion-weighted Imaging Versus Volume-based Parameter of 18F-FDG PET
Study cohort will undergo PET/CT and MRI scans prior to chemotherapy and after the first
chemotherapy cycle. MRI scans include DCE-MRI and DWI. The following parameters will be
calculated using these values:
1. Metabolic parameters on FDG-PET A. SUV change ratio (SCR) = SUVpost/SUVpre B. MTV
change ratio (VCR) = MTVpost/pre C. TLG change ratio = SCR X VCR
2. Perfusion parameters on DCE-MRI A. Kep B. K-trans C. ve
3. Diffusion parameters on DWI A. Mean ADC B. fDM
Observational
Observational Model: Case-Only, Time Perspective: Prospective
DWI, DCE-MRI, and FDG PET as early predictor for response and prognosis
The primary endpoint of this study is the prediction of one-year overall survival by monitoring the metabolic and functional responses of the tumor following one cycle of chemotherapy.
one year
No
Ho Yun Lee, Dr.
Principal Investigator
Samsung Medical Center
South Korea: Institutional Review Board
2011-05-087
NCT01482182
November 2011
December 2013
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