Inclusion Criteria:

1. Patients candidates to a chemotherapy treatment, with histologically or cytologically
confirmed malignant disease;

2. The concrete chemotherapy plan does not limited, group I (Highly Emetogenic
Chemotherapy), group II (Moderately Emetogenic Chemotherapy);

3. Male or female aged 18-75 years, ECOG≤2, estimates survival time≥3 months;

4. WBC≥3.0×109/L, ANC≥1.5×109/L, PLT≥80×109/L, total bilirubin≤1.5×ULN(Normal value
upper limit), AST and ALT≤2.5×ULN(With transferability liver cancer≤5×ULN), Cr and
BUN≤1.5×ULN, electrolyte and electrocardiogram are normal, conforms to the
chemotherapy adaptation;

5. Patients have been apart from the previous chemotherapy to finish above 2 weeks
(including 2 weeks);

6. Patients that voluntarily sign the consent form.

Exclusion Criteria:

1. Pregnancy, or patients during breast feeding;

2. Patients have accepted any radiotherapy during the experimental period;

3. Gastric outlet or intestinal obstruction;

4. Patients have serious heart diseases, liver kidney diseases, or metabolism function
disorder;

5. Patients have epilepsy, or have been used psychotropic drug and calm drug;

6. Received any drugs with potential anti-emetic efficacy, or experienced any vomiting,
nausea or retching in the 24 hours prior to chemotherapy;

7. Patients with transferability brain tumor, have vomiting caused by skull high
pressure, or can not speak sickness situation and adverse reactions by self;

8. Patients have known hypersensitivity to 5-HT3 antagonists;

9. Patients have chemotherapy contraindications;

10. Patients are participating, or have participated in other Clinical studies of new
drugs within 2 weeks.