Know Cancer

or
forgot password

MRI Assessment of Post-Radiation Change Following Stereotactic Body RT for Non-Small Cell Lung Cancer: A Pilot Study


N/A
18 Years
N/A
Open (Enrolling)
Both
Non Small Cell Lung Cancer

Thank you

Trial Information

MRI Assessment of Post-Radiation Change Following Stereotactic Body RT for Non-Small Cell Lung Cancer: A Pilot Study


Inclusion Criteria:



- Must have been treated at University of Health Network with SBRT for an early-stage
NSCLC (T1N0M0; T2N0M0; or T3N0M0 chest wall primary tumours only).

- On follow-up thoracic CT scans, patients must have changes in the previously targeted
lung parenchyma that fit into one of the following three patterns: - Changes that
on CT and clinical grounds are felt to be related to fibrosis

- Changes that on CT and clinical grounds are suspicious for recurrence

- Equivocal changes (uncertain whether the changes represent fibrosis or recurrence)

- Must be greater than 18 years in age

- Must be able to attend regular follow-up including radiologic investigations and
clinical visits

- Written informed consent

Exclusion Criteria:

- Standard contraindications to MRI study (e.g. ferromagnetic prosthesis,
pacemaker/implanted defibrillator, metallic implant in eye, severe claustrophobia,
etc…)

- Contraindications to Gadolinium contrast-agent. May include a history of allergic
reaction to following previous administration of gadolinium or poor renal function
(calculated creatinine clearance < 30 mL/min).

- Patients with surgical resection of the treated portion of lung following their SBRT,
although surgical resection of other parts of the lung is allowed.

Type of Study:

Interventional

Study Design:

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Optimal MRI parameters and sequences to characterize lung changes observed after SBRT for early-stage NSCLC.

Outcome Description:

MRI pulse sequence settings

Outcome Time Frame:

2 years

Safety Issue:

No

Principal Investigator

John Cho, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Health Network, Princess Margaret Hospital

Authority:

Canada: Ethics Review Committee

Study ID:

UHN REB 11-0079-CE

NCT ID:

NCT01480973

Start Date:

June 2011

Completion Date:

June 2014

Related Keywords:

  • Non Small Cell Lung Cancer
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

Name

Location