Inclusion Criteria:

1. 80 > Age >= 18 years.

2. Child-Pugh class A (class B could be included when Childs score is 7).

3. Hepatocellular carcinoma with major branch of portal vein invasion on dynamic CT or
MRI

- not only newly diagnosed treatment-naive patients,

- but also HCC patients previously treated with other therapies in case of
development of major branch of portal vein invasion

4. Adequate bone marrow, liver and renal function as assessed by the following
laboratory requirements:

- White blood cell counts (WBC) >= 2,000 /μl, Absolute neutrophil count (ANC) >
1,200/μl

- Hemoglobin >= 8.0 g/dl

- Platelet count > 50,000/μl

- Serum creatinine < 1.7 mg/dl

- Total bilirubin =< 3.0 mg/dl

- Prothrombin Time (PT)-international normalized ratio (INR) =< 2.3 or Prothrombin
Time (PT)-sec =< 6 sec

5. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2.

Exclusion Criteria:

1. Child-Pugh score >= 8.

2. Age < 18 or >= 80 years.

3. ECOG Performance Status >= 3.

4. Recipient of living donor or deceased donor liver transplantation

5. Patients unable to understand the contents of informed consent or refuse to sign the
informed consent.

6. Patients with evidence of uncontrolled or severe medical conditions requiring
treatment.