Step Down Colon Cancer Risk: A Pilot Intervention for Colon Cancer Risk Reduction
Primary Aim: To conduct a dose response pilot trial of low (30 min/day) or high (60 min/day)
dose exercise in men and women at increased risk of colon cancer. The major outcomes are
changes in serum levels of four risk-related biomarkers: insulin, C-peptide, IL-6 and PGE-2.
Secondary Aim. To compare changes in the secondary outcome of physical activity over three
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Exercise will decrease serum markers (insulin, C-peptide, IL-6 and PGE-2) in a dose response manner.
Changes in serum levels of four risk-related biomarkers: insulin, C-peptide, IL-6 and PGE-2 comparing baseline and 3 months serum levels.
Kathleen Y. Wolin, ScD, FACSM
Washington University School of Medicine
United States: Institutional Review Board
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