Inclusion Criteria:

- Patients between the ages of 18 and 80 years old

- As per self report and/or medical record female patients are either postmenopausal or
not able to become pregnant

- Patients with biopsy proven or suspected non-small cell lung cancer planned to
undergo induction chemotherapy and surgery, OR with biopsy proven or suspected
non-small cell lung cancer planned to undergo immediate surgical resection

- No clinical/neurological symptoms suggestive of brain metastases by attending's
judgment as documented in the medical record and/or correspondence with the research
team

- In the judgement of the consenting professional, patient is able to understand
English, through verbal and written communication

- Patient is able to undergo MRI scanning (verified with pre-MRI Safety Screening form
(Appendix A) used in MSKCC MRI Centers) completed at screening and again prior to
having the MRI.

Exclusion Criteria:

- Patients with history of significant neurological diagnoses including stroke, tumor,
dementia, epilepsy, or multiple sclerosis as indicated by medical records and/or self
report

- History of head injury with evidence of brain injury or loss of consciousness for >
60 minutes as per EMR or self-report

- No prior treatment with chemotherapy

- Participant has dentures, body jewelry or wig that they are unable to remove as per
self-report

- Patient reports that he/she cannot undergo MRI scanning without significant distress
or discomfort

- Significant psychiatric or cognitive disturbance sufficient, in the investigator's
judgment, to preclude providing informed consent or participating in the study (i.e.,
schizophrenia).