Inclusion Criteria

Part 1

Inclusion Criteria

- > 18 years

- WHO 0,1,2

- Suspicion of malignant glioma on contrast-enhanced MRI

- Able to give written informed consent

Exclusion Criteria

- Meningeal carcinomatosis, uncontrolled seizures, or a disease that either causes or
threatens neurologic compromise

- Pregnant or nursing women

- Known allergy to component of 89Zr-GC1008

- Significant medical or psychosocial problems

Part 2

Inclusion Criteria

- Relapsed malignant glioma

- Patient may have undergone surgery for the recurrence. Residual and measurable
disease after surgery is not required. Surgery must have confirmed the recurrence.
Post-operative MRI must be made within 48 hours following surgery

- For non operated patients, recurrent disease must be at least one bidimensionally
measurable target lesion (contrast enhancing lesion) with one diameter of at least
2cm, based on MRI scan done within 4 weeks prior to start of treatment

- 18 years

- WHO 0,1,2

- Serum albumin ≥3.0 g/dL

- Adequate organ function including:

- Hb ≥10.0 g/dL

- ANC ≥1,500/mm3

- platelets ≥100,000/mm3

- Serum total bilirubin ≤1.5 x ULN (Patients with Gilbert's Disease may be
included if their total bilirubin is ≤3.0 mg/dL)

- ALT and AST ≤2.5 x ULN.

- Estimated or measured creatinine clearance ≥60 mL/min

- PT and PTT within normal ranges

- Negative tests for hepatitis viruses B and C and HIV, unless the result is consistent
with prior vaccination or prior infection with full recovery

- Enrollment >4 weeks since major surgery, radiotherapy, chemotherapy (≥6 weeks if they
were treated with a nitrosourea, mitomycin, or monoclonal antibodies), immunotherapy,
or biotherapy/targeted therapies and recovered from the toxicity of prior treatment
to ≤ Grade 1, exclusive of alopecia. Concurrent cancer therapy is not permitted
(except for corticosteroids) (For long acting agents, a treatment free interval of 2
half lives should be considered)

- Able to give written informed consent

- Patients of child-producing potential must agree to use effective contraception while
enrolled on study and receiving the experimental drug, and for at least 3 months
after the last treatment

Exclusion Criteria

- History of ascites or pleural effusions , unless successfully treated, completely
resolved, and the patient has not been treated for these conditions for >4 months

- Active thrombophlebitis, thromboembolism, hypercoagulability states, bleeding, or use
of anti-coagulation therapy. Patients with a history of deep venous thrombosis may
participate if successfully treated, completely resolved, and no treatment has been
given for >4 months

- Hypercalcemia: Calcium >11.0 mg/dL (2.75 mmol/L) unresponsive or uncontrolled in
response to standard therapy

- Pregnant or nursing women

- Diagnosis with another malignancy - unless following curative intent therapy, the
patient has been disease free for at least 5 years and the probability of recurrence
of the prior malignancy is <5%. Patients with curatively treated early stage squamous
cell carcinoma of the skin, basal cell carcinoma of the skin, or cervical
intraepithelial neoplasia are eligible for this study

- Organ transplant, including allogeneic bone marrow transplant

- Investigational agents used within 4 weeks prior to study enrollment (within 6 weeks
for long-acting agents such as a monoclonal antibody)

- Immunosuppressive therapy including: cyclosporine A, tacrolimus, or sirolimus

- Significant or uncontrolled medical illness, such as congestive heart failure,
myocardial infarction, symptomatic coronary artery disease, significant ventricular
arrhythmias within the last 6 months, or significant pulmonary dysfunction. Patients
with a remote history of asthma or active mild asthma may participate

- Active infection, including unexplained fever (temperature >38.1 'C), or antibiotic
therapy within 1 week prior to enrollment

- Systemic autoimmune disease

- Known allergy to component of GC1008 or 89Zr-GC1008

- Significant medical or psychosocial problems