Inclusion Criteria:

- Initial diagnosis of metastatic pancreatic cancer must have occurred ≤6 weeks prior
to the completion of screening.

- The presence of measurable metastatic pancreatic cancer documented by contrast
enhanced CT (or MRI) scan in addition to 1 of the following:

1. Histological diagnosis of pancreatic adenocarcinoma confirmed by pathologist OR

2. Pathologist confirmed histological/cytological diagnosis of adenocarcinoma
consistent with pancreatic origin in conjunction with either:

1. The presence of a mass in the pancreas OR

2. A history of resected pancreatic carcinoma

- Measurable disease per RECIST (ver. 1.1)

- ECOG Performance Status of 0 or 1.

- Adequate hepatic, hematologic and renal functions.

Exclusion Criteria:

- A history or evidence of clinically significant disorder other than metastatic cancer
of the pancreas.

- A diagnosis of pancreatic islet neoplasms.

- Subject has undergone major surgery other than diagnosis surgery within 4 weeks of
randomization

- Presence of biliary obstruction requiring external drainage

- Brain metastases.

- Unstable cardiovascular function within the last 6 months of screening

- Clinically active liver disease, including active viral hepatitis (HBV or HCV) or
cirrhosis

- Known HIV infection.

- Uncontrolled hypertension at Screening

- History or presence of any form of cancer, other than pancreatic cancer, within the 3
years prior to enrollment

- Prior or concurrent anti-tumor therapy (chemotherapy, antibody therapy, molecular
targeted therapy, retinoid therapy, hormonal therapy) for the treatment of inoperable
locally advanced or metastatic pancreatic cancer; prior radiotherapy and chemotherapy
given as pre-operative neoadjuvant therapy or radio sensitizers for locally advanced
pancreatic cancer are allowed.

- Uncontrolled systemic fungal, bacterial or viral infection

- Participation in an investigational drug or device trial with therapeutic intent
within 30 days prior to study