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Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer


N/A
25 Years
80 Years
Not Enrolling
Both
Colorectal Cancer, Colon Rectal Resection, Oxidative Stress

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Trial Information

Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer


Study of the impact of surgery on Lipid peroxidation, Protein peroxidation, damage by
nitrogens, and RNA peroxidation, in patients undergo surgical resection for colorectal
cancer and compared with controls, and validation of the responsiveness of oxidative stress
markers on surgery


Inclusion Criteria:



- Patients with colorectal cancer

- Controls

Exclusion Criteria:

- ASA>3

- Metastatic Disease

- Acute bowel obstruction

- Acute bowel perforation

- BMI<30

- Chronic Systemic or Autoimmune Diseases

- Smokers

- Alcohol consumers

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)

Outcome Measure:

Comparison of Oxidative stress markers in patients with colorectal cancer and controls

Outcome Description:

Oxidative stress markers variation (8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG) during and after surgery for colorectal cancer, and compare with controls

Outcome Time Frame:

up to 2 years

Safety Issue:

No

Principal Investigator

George Pappas-Gogos, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

G. Hatzikosta General Hospital

Authority:

Greece: Ethics Committee

Study ID:

GH-1948-08

NCT ID:

NCT01470586

Start Date:

May 2009

Completion Date:

June 2011

Related Keywords:

  • Colorectal Cancer
  • Colon Rectal Resection
  • Oxidative Stress
  • Colorectal cancer
  • Surgical resection
  • Oxidative Stress Markers
  • Controls
  • Colorectal Neoplasms

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