The Treatment of Stage I and II Carcinoma of the Breast With Mastectomy and Axillary Dissection vs. Excisional Biopsy, Axillary Dissection, and Definitive Irradiation
Patients with biopsy proven breast cancer, clinical stage I and II, will be randomized to
receive treatment by one of two methods: (1) total mastectomy and axillary dissection; or
(2) excisional biopsy, axillary dissection, and definitive irradiation.
Data from single institutions and from retrospective comparisons suggest that definitive
irradiation with cosmetically acceptable breast preservation offers survival and local
control results equivalent to extirpative surgery. This study will test this hypothesis in
a prospective, randomized manner. After primary therapy, subjects will be followed for:
(1) survival; (2) sites of recurrence; (3) anatomic function; (4) complications of therapy;
and (5) cosmesis.
Primary Purpose: Treatment
Kevin A Camphausen, M.D.
National Cancer Institute (NCI)
United States: Federal Government
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Bethesda, Maryland 20892|