A Randomized Control Trial for the Effect of Honey on Radiotherapy Induced Xerostomia and Oral Mucositis in Patients With Head and Neck Cancers
Radiation-induced mucositis is a normal acute side effect of radiotherapy treatment.
Exposure of ionising radiation to oral, pharyngeal and laryngeal mucosa gives rise to
radiation epithelitis towards the second and third weeks of conventional fractionated
radiotherapy. Likewise, salivary flow may decrease by approximately 50% during the first
week of radiotherapy and upwards of 80% by the seventh week of treatment. Acute
radiation-induced xerostomia is associated with inflammatory reaction. The study will
include an intervention and a control group, one receiving honey prior and after the
radiotherapy and the other group not receiving honey at all.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Change from baseline in Xerostomia grades
1 week, 2 weeks, 3 weeks, 4 weeks
Andreas Charalambous, PhD
Cyprus University of Technology
Cyprus: Ministry of Health