Inclusion Criteria:

1. Between 35-58 years of age

2. At least 4 vasomotor symptoms (VMS) per day, on average, for at least 2/4 weeks or at
least 56 over a four-week period. In addition, women should report having VMS of
moderate or severe rather than mild intensity. Women reporting fewer VMS than this,
but who report night sweats that awaken them from sleep on two or more nights per
week will also be included.

3. Perimenopausal status either based on irregularity of menstrual periods, or by onset
of new perimenopausal symptoms in women with regular periods.

4. Ability and willingness to complete the Daily Perimenopause Diary recording
instrument.

5. Ability to understand, speak, read and write English.

6. Normal clinical breast examination within the 12 months of study enrollment (Health
Canada requirement).

7. If over 40, normal mammogram within 12 months of study enrollment (Health Canada
requirement).

Exclusion Criteria:

1. Less than 35 or greater than 58 years of age

2. No VMS, or VMS not meeting inclusion criteria, or VMS without perimenopausal etiology

3. More than 1-yr without menstrual flow, including those with a hysterectomy, +/-
ovariectomy

4. Peanut allergy (because peanut oil is used in the progesterone formulation)

5. Current or recent (within the last 6-mos.) use of hormonal therapies (estrogen,
progesterone, progestin-releasing IUD, hormonal contraceptives, hormonal fertility
treatments), or plans to initiate use during the study period

6. Planned pregnancy or fertility treatment during the study period

7. Inability to understand, speak, read and write English

8. Women age 40 or older without a normal mammogram within 12 months of study enrollment
(Health Canada requirement).

9. Women who have not had a normal clinical breast examination within 12 months of study
enrollment (Health Canada requirement).