Inclusion Criteria:

1. Patients must have histologically confirmed adenocarcinoma of the pancreas that is
metastatic and for which potential curative measures, such as resection of an
isolated metastasis, are not available. Patients with islet cell neoplasms are
excluded.

2. Patient has one or more metastatic tumors measurable by CT scan AND a serum CA19-9
measurement > 2 times the upper limit of normal. Patients must have measurable
disease, defined as at least one lesion that can be accurately measured in at least
one dimension (longest diameter to be recorded for non-nodal lesions and short axis
for nodal lesions) as >20 mm with conventional techniques or as >10 mm with spiral CT
scan.

3. Male or non-pregnant and non-lactating female and ≥ 18 to ≤ 75 years of age. If a
female patient is of child-bearing potential, she must have a negative serum
pregnancy test documented within 72 hours prior to the first administration of study
drug and on Day 1 of each cycle thereafter. If sexually active, the patient must
agree to use contraception prior to study entry and for the duration of study
participation.

4. Patients must have received no prior radiotherapy or chemotherapy for metastatic
disease. Patients who have received radiotherapy or chemotherapy as adjuvant o
neo-adjuvant therapy for locally advanced disease six months or more prior to
enrollment into this study are eligible.

5. Patient has adequate biological parameters as demonstrated by the following blood
counts at Screening (obtained ≤ 14 days prior to randomization) and at Baseline-Day
0: Absolute neutrophil count (ANC) ≥ 1.5 × 109/L; Platelet count ≥ 100,000/mm3 (100 ×
109/L); Hemoglobin (Hgb) ≥ 9 g/dL.

6. Patient has the following blood chemistry levels at Screening (obtained ≤ 14 days
prior to randomization) and at Baseline-Day 0:

- AST (SGOT), ALT (SGPT) ≤ 2.5 × upper limit of normal range (ULN), unless liver
metastases are present, then ≤ 5 × ULN is allowed. Total bilirubin ≤ 1.5 × ULN.

- Serum creatinine (Cr) within normal limits or calculated clearance ≥ 60
mL/min/1.73 m2 for patients with creatinine (Cr) levels above or below the
institutional normal value. If using Cr clearance, actual body weight should be
used for calculating Cr clearance (e.g., using the Cockcroft-Gault formula).

7. Patient has acceptable coagulation studies at Screening (obtained ≤14 days prior to
randomization) as demonstrated by prothrombin time (PT) and partial thromboplastin
time (PTT) within normal limits (± 15%).

8. Patient has ECOG performance status ≤ 1.

Exclusion Criteria:

1. Patient has brain metastases.

2. Patient has only locally advanced disease.

3. Patient has experienced an increase of ECOG to > 1 between Screening and
Randomization.

4. Patient requires continuous treatment with coumadin or other oral or parenteral
anticoagulation (heparin, LMWH, heparinoids) to prevent or treat thromboembolic
disease. The use of prophylactic antiplatelet drugs such as clopidogrel and aspirin
are allowed before and during the study.

5. Patient has active, uncontrolled bacterial, viral, or fungal infection(s) requiring
systemic therapy.

6. Patient has undergone major surgery, other than diagnostic surgery (i.e.--surgery
done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks
prior to Randomization in this study.

7. Patient has a history of allergy or hypersensitivity to any of the study drugs, their
pharmaceutical class or any of their excipients.

8. Patient has a concomitant serious medical or psychiatric illness that, in the opinion
of the investigator, could compromise the patient's safety or the study data
integrity.

9. Patient is enrolled in any other clinical protocol or investigational trial
involving administration of antineoplastic compounds for the treatment of metastatic
pancreatic cancer.

10. Patient is unwilling or unable to comply with study procedures.

11. Nab-paclitaxel is metabolized by CYP2C8 and CYP3A4. Co-administration of substrates,
inhibitors of CYP2C8 and/or CYP3A4 with nab-paclitaxel is not allowed. The following
medications and substances are not allowed during the study: ritonavir, saquinavir,
indinavir, nelfinavir, rifampicin, carbamazepine, phenytoin, efavirenz, or
nevirapine, grapefruit (juice or seeds) or some herbals like St. John's wort.

12. Subjects with risk factors for or a history of Torsades des Pointes (TdP), or a
significant QT prolongation that in the opinion of the investigator may place the
study subject at risk.