Randomized Clinical Trial to Compare Air Versus Carbon Dioxide in Screening Unsedated Colonoscopy.
The study was conducted in 200 consecutive patients undergoing screening colonoscopies for
the detection of early colon cancer. The examinations were performed with Olympus 165
colonoscopes by seven experienced endoscopists, each of whom performed alone about over 2000
colonoscopies. The patients were randomly assigned to Group I and II with either air or
carbon dioxide insufflation. Both study groups were matched by sex, age, duration of the
procedure, and BMI. The authors compared for the duration of the procedure, coecal
intubation time, complication rate, pulse rates immediately after the procedure, 15 minutes
after, and subjective pain evaluation on a Visual Analogue Scale.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Screening
duration of procedure
Time from introduction of a colonoscope to removal of the colonoscope.
Miroslaw Szura, MD PhD
I Dept of General, Oncological and GI Surgery Jagiellonian University
Poland: Ministry of Health
Cracow CO2 Trial