Inclusion Criteria:

- Confirmed diagnosis of multiple myeloma that is relapsed and/or refractory for which
no curative option exists.

- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2.

- During the dose expansion part of the study patients must have measurable disease
defined by at least 1 of the following 2 measurements:

- Serum M-protein ≥ 0.5 g/dL

- Urine M-protein ≥ 200 mg/24 hours

Exclusion Criteria:

- Patients who are currently receiving treatment with medications that meet one of the
following criteria and that cannot be discontinued at least one week prior to the
start of treatment with LGH447:

- Strong inhibitors or inducers of CYP3A4

- CYP3A4 substrates with narrow therapeutic index

Other protocol-defined inclusion/exclusion criteria may apply.