Inclusion Criteria

Inclusion criteria:

Patients with epithelial ovarian cancer FIGO (Fédération Internationale de Gynécologie et
d'Obstétrique) stage III in remission after treatment with surgery (hysterectomy and
ovariectomy) and after the first primary chemotherapy (standard treatment e.g. 6-9x
Carboplatin/Taxane)

- Age > 18 ≤ 75 years

- Histological confirmed FIGO stage III ovarian epithelial cancer

- Stable disease at screening visit: negative CT and CA-125 within normal range

- Karnofsky status ≥ 70% and/or ECOG (Eastern Cooperative Oncology Group) performance
status 0-2

- Life expectancy ≥ 6 months

- Adequate hematological function (WBC (white blood cells) ≥ 3000/µl, hemoglobin ≥ 10.0
g/dL, platelets > 100,000/µl)

- Adequate renal and hepatic function (serum creatinine ≤ 2.0 mg/dL, bilirubin total <
2 mg/dL, PT (INR) ≤ 1.5x institutional upper limit of normal)

- Signed and dated informed consent before the start of any study-specific procedure

- Body weight > 50 kg

Exclusion criteria:

- Surgery, radiation therapy or chemotherapy within eight weeks prior to leukapheresis

- Other biological therapy (Interferons, TNF (Tumor necrosis factors), Interleukins,
mABs (Monoclonal antibodies), biological response modifiers) within eight weeks prior
to undergo the leukapheresis

- History or presence of systemic autoimmune disease (such as, but not restricted to,
inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis,
scleroderma or multiple sclerosis)

- Participation in other clinical trials or treatments with an investigational drug
within four weeks prior to enrollment

- Serious intercurrent chronic or acute illness such as severe asthma or COPD (Chronic
Obstructive Pulmonary Disease), cardiac (NYHA (New York Heart Association ) class III
or IV) or hepatic disease, or other illness considered to constitute an unwarranted
high risk for investigational drug treatment

- History of another malignancy within five years prior to study enrollment, except
curatively treated non-melanotic skin cancer or cervical cancer in situ

- Presence of an active acute or chronic infection, including syphilis, HIV or viral
hepatitis B and/or C

- Current treatment with corticosteroids (except of local) or other immunosuppressive
agents such as azathioprine or cyclosporine A is excluded on the basis of its
potential immune suppression. Any systemic steroid therapy must have been
discontinued six weeks prior to undergo the leukapheresis

- Patients who have undergone organ transplantation

- Legally incapacitated persons and/or other circumstances, which make it difficult for
the subject to understand the nature, meaning and consequences of the clinical study