Analysis of Immune Reactions Occurring in Normal Volunteers Upon Administration of the Topical Immunomodulator Diphenylcyclopropenone
The immune system is the primary line of defense against infections and other things
perceived as foreign to the body. Unfortunately, this immune system often fails to
eliminate tumors or other cancerous growths. The drug diphenylcyclopropenone, or DPCP,
modifies the immune system and has been shown to be effective in treating certain kinds of
cancer. This study hopes to improve our understanding of how this drug helps create an
effective immune response. In order to reach this goal, normal volunteers will be given the
DPCP drug in the form of a gel or a placebo gel (gel without the active chemical) on a few
small areas of skin. Then, biopsies will be taken of the skin at the sites where the active
drug was placed. Also, small biopsies will be taken from opposite areas of skin which
received placebo gel to serve as controls. The biopsied skin samples will then be studied
by methods such as immunohistochemistry and microarray analysis which will help define the
immune reaction caused by DPCP. The rationale for the study is to better understand how the
immune system can be activated to produce cells that may fight infections or cancers.
Observational
Observational Model: Cohort, Time Perspective: Prospective
James Krueger, MD,PhD
Principal Investigator
Rockefeller University
United States: Institutional Review Board
JKR-0742
NCT01452594
October 2011
October 2013
Name | Location |
---|---|
The Rockefeller University | New York, New York 10065 |