Trial Information

Randomized Comparison of Steretotactic Radiosurgery and Hypofractionated Steretotactic Radiotherapy in the Treatment of Vestibular Schwannoma

Vestibular schwannomas (VSs) are slow-growing tumors of the myelin-forming cells that cover
cranial nerve VIII.The treatment options for patients with VSs include active observation,
surgical management, and radiotherapy. However, the optimal treatment choice remain
controversial.

Over the past 10 years, there has been rapid progress in the application of stereotactic
radiotherapy to the treatment of VSs. The stereotactic radiotherapy program includes single
fraction radiosurgery (SRS) and hypofraction stereotactic radiotherapy (HSRT) are commonly
used for VSs treatment. Since SRS and SRT techniques differ significantly enough to raise
questions of therapeutic advantage and until now, there is no prospective, randomized study
comparing the outcomes for patients treated using both radiotherapy techniques. We designed
the first prospective randomized protocol to compare SRS and SRT for answer this question.