Inclusion Criteria:

- Histologically confirmed diagnosis of chordoma or chondrosarcoma.

- Patients must have no evidence of metastatic disease based on routine imaging (CT or
MRI of the chest/abdomen/pelvis, bone scan, etc.)

- Patients must have an ECOG score equal to or less than 2.

- Age ≥ 18 years.

- Patients must be able to provide informed consent.

- Adequate bone marrow function: WBC ≥ 4000/mm3, platelets ≥ 100, 000mm3

- Women of child-bearing potential as long as she agrees to use a recognized method of
birth control (e.g. oral contraceptive , IUD, condoms or other barrier methods etc.)
Hysterectomy or menopause must be clinically documented.

- Tumors arising in the skull and spine.

Exclusion Criteria:

- Prior or simultaneous malignancies within the past two years (other than cutaneous
squamous or basal cell carcinoma, melanoma in situ or thyroid carcinoma)

- Patients with the following histologies are excluded: melanoma , other soft tissue or
bony sarcomas, giant cell tumor aneurismal bone cyst or metastatic lesions from other
histologies.

- Pregnant women.

- Actively being treated on any other therapeutic research study.

- Tumors arising outside of the CNS.